After being introduced to the works of John E. Mack —especially a study by Mack which had reported that three percent of Americans claimed to have been abducted by aliens—Carter believed he had found his central theme. Although this decision never came to pass, the third season episode " Jose Chung's From Outer Space " can be seen as a holdover from the idea.
Tired of the comedies he had been working on for Walt Disney Pictures ,  inspired by a report that 3. He initially struggled over the untested concept—executives wanted a love interest for Scully—and casting. The network wanted either a more established or a "taller, leggier, blonder and breastier"  actress for Scully than the year-old Gillian Anderson , a theater veteran with minor film experience, who Carter felt was the only choice after auditions.
He fleshed out the concept and returned a few weeks later, leading to the commission of the pilot. The Night Stalker and The Twilight Zone in his youth; as well as from the then-recently released film The Silence of the Lambs , which was the impetus for framing the series around agents from the FBI , in order to provide the characters with a more plausible reason for being involved in each case than Carter believed was present in Kolchak.
However, unable to find suitable locations for many of the scenes, Ten Thirteen Productions made the decision to "go where the good forests are", and moved production to Vancouver ,  where the series would remain for the next five seasons; production would eventually shift to Los Angeles beginning with the sixth season.
But in his manager , Melanie Green, gave him a script for the pilot episode of series. Green and Duchovny were both convinced it was a good script, so Duchovny auditioned for the lead. Chris Carter thought at the beginning of the auditioning for the character, he was a "good judge of character", and thought that Duchovny wasn't rather "bright". So he went and talked to Duchovny and asked him if he could "please" imagine himself as an FBI agent for the "future" week.
The casting director of the show was very positive towards him. According to Carter, Duchovny turned out to be one of the best-read people he knew. This led Carter to insist that he did not want the roles of Mulder and Scully to become romantically involved, citing the relationship between the lead roles in Moonlighting as an example to avoid.
The character had been conceived as playing against the stereotypical bureaucratic "paper-pusher", being instead someone more "quietly dynamic". At first, the fact that he was asked back to audition for the role had puzzled him, until he discovered the reason he had not cast for the previous parts—Chris Carter had been unable to imagine Pileggi as any of those characters, due to the fact that the actor had been shaving his head.
When Pileggi attended the audition for Walter Skinner, he had been in a grumpy mood and had allowed his small amount of hair to grow back. Pileggi's attitude fit well with the character of Skinner, causing Carter to assume that the actor was only pretending to be grumpy. After successfully auditioning for the role, Pileggi thought he had been lucky that he had not been cast in one of the earlier roles, as he believed he would have appeared in only a single episode and would have missed the opportunity to play the recurring role of Walter Skinner.
The first season introduced the series' primary antagonist, Cigarette Smoking Man ,  and gave early insight into the disappearance of Mulder's sister Samantha , whose abduction provided one of the main plot threads of the series as a whole.
The finale was the first episode directed by R. Goodwin , who had served as producer for the series.